Page 67 - 中国药房（网络版）2022年2期_28_H

2022 年 6 月 第 2 期 叶飞：葡萄柚，神奇而危险的水果——关注药物食物间的相互作用 63

Pharmacol Ther,1997，61:395-400.
［4］BARTLE W R. Grapefruit juice might still be factor in warfarin response[J].Am J Health Syst Pharm,1999,
56:676.

［5］WIENS A.How does grapefruit juice affect psychotropic medications？ [J].J Psychiatry Neurosci,2000,25:198.
［ 6 ］GOLDBART A，PRESS J，SOFER S，et al. Near fatal acute colchicine intoxication in a child. A case report
[J]. Eur J Pediatr,2000,159:895-897.

［ 7 ］ADIGUN A Q，MUDASIRU Z. Clinical effects of grapefruit juice-nifedipine interaction in a 54-year-old
Nigerian：a case report[J]. J Natl Med Assoc,2002,94:276-278.
［ 8 ］HERMANS K，STOCKMAN D，VAN DEN BRANDEN F.Grapefruit and tonic：a deadly combination in a

patient with the long QT syndrome[J]. Am J Med,2003,114:511-512.
［9］DREIER J P，ENDRES M.Statin-associated rhabdomyolysis triggered by grapefruit consumption[J].Neurology,

2004,62:670.
［10］KARCH A M.The grapefruit challenge：the juice inhibits a crucial enzyme，with possibly fatal consequences
[J].Am J Nurs,2004,104:33-35.

［11］FUKATSU S，FUKUDO M，MASUDA S，et al.Delayed effect of grapefruit juice on pharmacokinetics and
pharmacodynamics of tacrolimus in a living-donor liver transplant recipient[J]. Drug Metab Pharmacokinet,
2006,21:122-125.

［12］TANIGUCHI K，OHTANI H，IKEMOTO T，et al.Possible case of potentiation of the antiplatelet effect of
cilostazol by grapefruit juice[J]. J Clin Pharm Ther,2007,32:457-459.
［13］PEYNAUD D，CHARPIAT B，VIAL T，et al.Tacrolimus severe overdosage after intake of masked grapefruit

in orange marmalade[J].Eur J Clin Pharmacol,2007,63:721-722.
［14］MAZOKOPAKIS E E. Unusual causes of rhabdomyolysis[J].Intern Med J,2008,38:364-367.

［15］GRANDE L A，MENDEZ R D，KRUG R T，et al，Attention--grapefruit！[J].Lancet ,2009,373:1222.
［16］PILLAI U，MUZAFFAR J，SEN S，et al. Grapefruit juice and verapamil：a toxic cocktail[J].South Med J,
2009,102:308-309.

［17］VALENZUELA B，REBOLLO J，PEREZ T，et al. Effect of grapefruit juice on the pharmacokinetics of
docetaxel in cancer patients：a case report[J].Br J Clin Pharmacol,2011,72:978-981.

作者简介

叶飞 陆军军医大学第二附属医院主管药师。研究方向：临床药学。