Page 74 - 202002
P. 74
注册编号:NCT02685345 [3] Brocker C, Thompson D C,
2016年1-9月 Vasiliou V. The role of hyperosmotic
stress in inflammation and disease[J].
Biomolecular concepts, 2012, 3(4): 345-
可见,DS-8500a可以显著改善血糖, 364.
与DPP-4抑制剂如西格列汀一起使用也展 [4] Nasteska D, Hodson D J.
现了较好的疗效。不过,有些研究指出, GPR119 Agonism Revisited: A Novel
GPR119活化可能影响骨骼肌和心肌的代 Target for Increasing β-Cell Mass?[J].
谢健康 [10] ,如诱发炎症等,因而GPR119 Endocrinology, 2020, 161(2): bqz018.
激动药的成药安全性有待进一步研究来证
实。若此药得以顺利地通过临床试验并成 [5] Overton H A, Fyfe M C T, Reynet
功上市,必然会为一些顽固性高血糖的糖 C. GPR119, a novel G protein‐coupled
尿病患者带来福音,愿未来研究者可以继 receptor target for the treatment of type 2
diabetes and obesity[J]. British journal of
续加大投入,早日推进该药物的研发。
pharmacology, 2008, 153(S1): S76-S81.
[6] Little T J, Isaacs N J, Young R L,
et al. Characterization of duodenal
expression and localization of fatty acid-
sensing receptors in humans:
relationships with body mass index[J].
American Journal of Physiology-
Gastrointestinal and Liver Physiology,
2014, 307(10): G958-G967.
[7] Soga T, Ohishi T, Matsui T, et al.
参考文献 Lysophosphatidylcholine enhances
[1] Williams R, Karuranga S, glucose-dependent insulin secretion via
Malanda B, et al. Global and regional an orphan G-protein-coupled receptor[J].
estimates and projections of diabetes- Biochemical and biophysical research
related health expenditure: results from communications, 2005, 326(4): 744-751.
the International Diabetes Federation
Diabetes Atlas[J]. Diabetes Research and [8] Dhayal S, Morgan N G. The
Clinical Practice, 2020: 108072. significance of GPR119 agonists as a
future treatment for type 2 diabetes[J].
[2] Rajesh P, Manish K, Deepmala V, Drug News Perspect, 2010, 23(7): 418-
et al. Antidiabetic effect of Morinda 424.
citrofolia and Coccinia indica in alloxan
induced diabetic rats[J]. Advances in Bio [9] Matsumoto K, Yoshitomi T,
Research, 2010, 1(1): 75-77. Ishimoto Y, et al. DS-8500a, an orally
available G protein-coupled receptor 119
agonist, upregulates glucagon-like
c̈́̽ḤḤc