Page 16 - 202002
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[2] 阮江雄,谢丽萍.人胰高血糖素样                                  [10]  Rosenstock  J,  Allison  D,

         肽-1受体激动药索马鲁肽的研究进展 [J].                               Birkenfeld  AL,  et  al.  Effect  of  Additional
         世界临床药物,2018.39(12):856-863.                          Oral  Semaglutide  vs  Sitagliptin  on
                                                              Glycated Hemoglobin in Adults With Type
              [3] 李艳梅,唐伟偌.索马鲁肤口服剂:
         开启GLP -1受体激动药的新时代 [J]. 药品                            2  Diabetes  Uncontrolled  With  Metformin

         评价,2019.16(24):1-5.                                  Alone      or    With     Sulfonylurea:      The
                                                              PIONEER 3 Randomized Clinical Trial [J].
              [4]  Vsramini  P,  Toth  I.  Recent             JAMA. 2019. 321(15): 1466-1480.

         advances  in  oral  delivery  of  peptide
         hormones  [J].  Expert  Opin  Drug  Deliv,                [11]  Pratley  R,  Amod  A,  Hoff  ST,  et
         2016, 13(4):507-522.                                 al.      Oral        semaglutide          versus
                                                              subcutaneous  liraglutide  and  placebo  in
              [5] 葛阳.口服GLP-1受体激动药的研究                          type     2    diabetes(PIONEER            4):    a

         进展[J].药物生物技术,2018,25(6):533-                         randomised,double-bfind,  phase  3a  trial
         536.                                                 [J]. Lancet, 2019, 394(10192): 39-50.


              [6] John D, Lauren G, Nicole Carter,                 [12]  Mosenzon  O,  Blicher  TM,
         et al. Oral Semaglutide: A Review of the             Rosenlund S, et al. Efficacy and safety of
         First    Oral    Glucagon-Like        Peptide-1      oral  semaglutide  in  patients  with  type  2
         Receptor Agonist [J] Diabetes Technology             diabetes        and        moderate         renal

         and Therapeutics,2019,22(1):1-27.                    impairment(PIONEER  5):  a  placebo-

              [7] Maher S, Mrsny RJ, Brayden DJ.              controlled, randomised, phase 3a trial [J].
         Intestinal  permeation  enhancers  for  oral         Lancet  Diabetes  Endocrinol,  2019,  7(7):

         peptide delivery [J]. Adv Drug Deliv Rev,            515-527.
         2016,106(PtB):277-319.                                    [13]  Husain  M,  Birkenfeld  AL,

              [8]  Aroda       VR,  Rosenstock           J,   Donsmark M, et al. Oral Semaglutide and

         Terauchi       Y,     et      al.     PIONEER        Cardiovascular Outcomes in Patients with
         1:Randomized  Clinical  Trial  of  the               Type 2 Diabetes [J]. N Engl J Med,2019,

         Efficacy  and  Safety  of  Oral  Semaglutide         381(9): 841-851.
         Monotherapy         in    Comparison        With          [14] Pieber TR, Bode B, Mertens A,
         Placebo in Patients With Type 2 Diabetes             et  al.  Efficacy  and  safety  of  oral
         [J].  Diabetes  Care,  2019,  42(9):  1724-          semaglutide with flexible dose adjustment

         1732.                                                versus        sitagliptin     in      type       2

              [9]  Rodbard  HW,  Rosenstock  J,               diabetes(PIONEER  7):  a  multicentre,
         Canani  LH,  et  al.  Oral  Semaglutide              open-label,  randomised,  phase  3a  trial

         Versus  Empagliflozin  in  Patients  With            [J].  Lancet  Diabetes  Endocrinol,  2019,
         Type     2    Diabetes      Uncontrolled       on    7(7): 528-539.

         Metformin:The  PIONEER  2  Trial  [J].
         Diabetes Care, 2019, 42(12): 2272-2281.




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