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2025 年 12 月 第 6 期                       汪龙等:凝血针砭录——口服抗凝药与食饮相冲事                                29




                  新药新规,善用须知



                   凝血之道,如履薄冰。然医者论文亦坦承,诸多相冲之说,证据尚薄弱。有试验样本寥寥

              可数,有案例或属偶然。然生命岂能赌概率?吾辈当持“宁过慎,毋放纵”之念。昔华佗刮骨疗


              毒,今人服药防栓,皆是与命相搏。抗凝药乃科学利刃,然若不知食饮相冲之理,无异持刃自

              戕。愿诸君谨记,盘中寻常物,或成腹内虎。慎之,慎之!




              基金项目:蚌埠市科技创新指导类项目(2024ZD0050)




                  参考文献



                  [1]  TALASAZ  AH,  MCGONAGLE  B,  HAJIQASEMI  M,  et  al.  Pharmacokinetic  and  pharmacodynamic

                      interactions  between  food  or  herbal  products  and  oral  anticoagulants:  evidence  review,  practical

                      recommendations, and knowledge gaps[J]. Semin Thromb Hemost, 2025, 51(5): 560-571.

                  [2] HOLBROOK AM, PEREIRA JA, LABIRIS R, et al. Systematic overview of warfarin and its drug and

                      food interactions[J]. Arch Intern Med, 2005, 165(10): 1095-1106.


                  [3]  CHANG  CH,  WANG  YW,  YEH  LIU  PY,  et  al.  A  practical  approach  to  minimize  the  interaction  of

                      dietary vitamin K with warfarin[J]. J Clin Pharm Ther, 2014, 39(1): 56-60.

                  [4]  LILJA  JJ,  BACKMAN  JT,  NEUVONEN  PJ.  Effects  of  daily  ingestion  of  cranberry  juice  on  the

                      pharmacokinetics of warfarin, tizanidine, and midazolam probes of CYP2C9, CYP1A2, and CYP3A4

                      [J]. Clin Pharmacol Ther, 2007, 81(6): 833-839.

                  [5]  ANSELL  J,  MCDONOUGH  M,  ZHAO  Y,  et  al.  The  absence  of  an  interaction  between  warfarin  and

                      cranberry juice: a randomized, double-blind trial[J]. J Clin Pharmacol, 2009 , 49(7): 824-830.

                  [6]  MONTERREY-RODRÍGUEZ  J.  Interaction  between  warfarin  and  mango  fruit[J].  Ann  Pharmacother,

                      2002, 36(5): 940-941.

                  [7]  KOMPERDA  KE.  Potential  interaction  between  pomegranate  juice  and  warfarin[J].  Pharmacotherapy,

                      2009, 29(8): 1002-1006.

                  [8]  JIANG  X,  WILLIAMS  KM,  LIAUW  WS,  et  al.  Effect  of  St  John's  wort  and  ginseng  on  the
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